Wnt signalling and its impact on development and cancer

  title={Wnt signalling and its impact on development and cancer},
  author={Alexandra Klaus and Walter Birchmeier},
  journal={Nature Reviews Cancer},
The Wnt signalling pathway is an ancient system that has been highly conserved during evolution. It has a crucial role in the embryonic development of all animal species, in the regeneration of tissues in adult organisms and in many other processes. Mutations or deregulated expression of components of the Wnt pathway can induce disease, most importantly cancer. The first gene to be identified that encodes a Wnt signalling component, Int1 (integration 1), was molecularly characterized from mouse… 
3 ) Wnt signaling in Embryonic Development and Homeostasis
A major challenge resides in developing a strategy efficient enough to target the dysregulated Wnt pathway in CSCs, while being safe enough to not damage the normal somatic stem cell population required for tissue homeostasis and repair.
The way Wnt works: Components and mechanism
How the critical Wnt pathway component, β-catenin, is in a “futile cycle” of constant synthesis and degradation and how this cycle is disrupted upon pathway activation is described.
Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage
The function played by Fzd6 in the physiology of normal and cancer cells has been highlighted in the view that an increased knowledge of the signalling pathways upstream and downstream of this receptor could ultimately result in the identification of new targets for cancer therapy.
The Wnt signaling pathway in cancer.
WNT Signaling in Neuroblastoma
Developmental and clinical aspects of WNT signaling in neuroblastoma (NB), an embryonic tumor with an extremely broad clinical spectrum, ranging from spontaneous differentiation to fatal outcome are discussed and implications in NB onset, progression, and relapse due to chemoresistance are discussed.
Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches
The molecular mechanism(s) underlying the crosstalk between Wnt-signalling components (canonical and non-canonical) and miRNAs, as well as changes in the miRNA/Wnt-Signalling components observed in the different forms of cancer are overviewed.
Wnt signaling in cancer.
  • P. Polakis
  • Biology
    Cold Spring Harbor perspectives in biology
  • 2012
The evidence supporting a role for Wnt signaling in human cancer is summarized, including a review of the genetic mutations affecting Wnt pathway components, as well as some of epigenetic mechanisms that alter expression of genes relevant to Wnt.


A new nuclear component of the Wnt signalling pathway
The discovery is reported of pygopus (pygo), whose mutant phenotypes specifically mimic loss-of-Wingless (Wg) signalling, and it is proposed that they mediate chromatin access to TCF or Arm/β-catenin.
Functional Genomic Analysis of the Wnt-Wingless Signaling Pathway
High-throughput RNAi screens in cultured cells, followed by functional analyses in model organisms, prove to be a rapid means of identifying regulators of signaling pathways implicated in development and disease.
An LDL-receptor-related protein mediates Wnt signalling in mice
Evidence is presented that a new member of the low-density lipoprotein (LDL)-receptor-related protein family, LRP6, is critical for Wnt signalling in mice, and a genetic enhancement of a Wnt mutant phenotype in mice lacking one functional copy of LRP 6 is shown.
MicroRNA control of Nodal signalling
It is reported that Xenopus laevis microRNAs miR-15 andMiR-16 restrict the size of the organizer by targeting the Nodal type II receptor Acvr2a.
The Wnt/β-Catenin Signaling Pathway as a Target in Drug Discovery
An overview of the Wnt/β-catenin signaling pathway: its roles in physiology and pathology and the possibility as a target in development of new drugs is provided.
Wnt proteins are lipid-modified and can act as stem cell growth factors
This work isolated active Wnt molecules, including the product of the mouse Wnt3a gene, and found the proteins to be palmitoylated on a conserved cysteine, indicating that the lipid is important for signalling.
Caught up in a Wnt storm: Wnt signaling in cancer.
Distinct Wnt signaling pathways have opposing roles in appendage regeneration
It is shown that Wnt/β-catenin signaling is activated in the regenerating zebrafish tail fin and is required for formation and subsequent proliferation of the progenitor cells of the blastema, and that fin regeneration is accelerated in wnt5b mutant fish.