Wnt signaling regulates symmetry of division of neural stem cells in the adult brain and in response to injury.

@article{Piccin2011WntSR,
  title={Wnt signaling regulates symmetry of division of neural stem cells in the adult brain and in response to injury.},
  author={David Piccin and Cindi M Morshead},
  journal={Stem cells},
  year={2011},
  volume={29 3},
  pages={528-38}
}
Neural stem cells comprise a small population of subependymal cells in the adult brain that divide asymmetrically under baseline conditions to maintain the stem cell pool and divide symmetrically in response to injury to increase their numbers. Using in vivo and in vitro models, we demonstrate that Wnt signaling plays a role in regulating the symmetric… CONTINUE READING