Wnt signaling regulates pulp volume and dentin thickness.

  title={Wnt signaling regulates pulp volume and dentin thickness.},
  author={Won Hee Lim and Bo Yang Victor Liu and Du Cheng and Daniel J Hunter and Zhendong Zhong and Daniel M. Ramos and Bart O. Williams and Paul T Sharpe and Claire Bardet and Su-jung Mah and J A Helms},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={29 4},
Odontoblasts, cementoblasts, ameloblasts, and osteoblasts all form mineralized tissues in the craniofacial complex, and all these cell types exhibit active Wnt signaling during postnatal life. We set out to understand the functions of this Wnt signaling, by evaluating the phenotypes of mice in which the essential Wnt chaperone protein, Wntless was eliminated. The deletion of Wls was restricted to cells expressing Osteocalcin (OCN), which in addition to osteoblasts includes odontoblasts… CONTINUE READING