Wnt signaling regulates hemopoiesis through stromal cells.

  title={Wnt signaling regulates hemopoiesis through stromal cells.},
  author={Takahiro Yamane and Takahiro Kunisada and Hidekazu Tsukamoto and Hidetoshi Yamazaki and Hirokatsu Niwa and Satoshi Takada and S I Hayashi},
  journal={Journal of immunology},
  volume={167 2},
Hemopoietic cells develop in a complex milieu that is made up of diverse components, including stromal cells. Wnt genes, which are known to regulate the fate of the cells in a variety of tissues, are expressed in hemopoietic organs. However, their roles in hemopoiesis are not well characterized. In this study, we examined the roles of Wnt proteins in hemopoiesis using conditioned medium containing Wnt-3a. This conditioned medium dramatically reduced the production of B lineage cells and myeloid… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 37 extracted citations

Role of WNT signaling in normal and malignant hematopoiesis.

Histology and histopathology • 2006
View 5 Excerpts
Highly Influenced

Mouse Yolk Sac Hematopoiesis

Front. Cell Dev. Biol. • 2018
View 3 Excerpts

Wnt Signaling: Role in Regulation of Haematopoiesis.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…