Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung.

@article{Tang2006WntSP,
  title={Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung.},
  author={Moying Tang and Juan Torres-Lanzas and Fernando L{\'o}pez-R{\'i}os and Manel Esteller and Montserrat S{\'a}nchez-C{\'e}spedes},
  journal={International journal of cancer},
  year={2006},
  volume={119 11},
  pages={2603-6}
}
Promoter hypermethylation is responsible for gene inactivation during carcinogenesis. It has been proposed that there is some degree of specificity in the set of genes that become altered by this mechanism in distinct tumor types. To understand whether promoter hypermethylation may differentiate the site of origin, 49 lung adenocarcinomas from 31 lung primaries and 18 metastases from colorectal primaries, respectively, were tested for the presence of this alteration in the APC, CDH1, DAPK… CONTINUE READING
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