Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1.

Abstract

During vertebrate embryogenesis, vascular endothelial cells (ECs) and primitive erythrocytes become specified within close proximity in the posterior lateral plate mesoderm (LPM) from a common progenitor. However, the signaling cascades regulating the specification into either lineage remain largely elusive. Here, we analyze the contribution of β-catenin… (More)
DOI: 10.1016/j.ydbio.2017.08.004

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