Wnt-signaling pathways in progressive renal fibrosis.

  title={Wnt-signaling pathways in progressive renal fibrosis.},
  author={Peter Jon Nelson and Christine von Toerne and Hermann-Josef Gr{\"o}ne},
  journal={Expert opinion on therapeutic targets},
  volume={15 9},
INTRODUCTION The prevention and potential reversal of interstitial fibrosis is a central strategy for the treatment of progressive renal disease. This strategy requires a better understanding of the underlying pathophysiologic processes involved in progressive renal fibrosis. AREAS COVERED The developmental processes in which Wnt (combination of 'wingless' and 'INT')/frizzled signaling is involved is discussed in this review, including cell fate determination, cell polarity, tissue patterning… CONTINUE READING
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