Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations.

  title={Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations.},
  author={Ginny G. Farias and Juan Alejandro Godoy and Waldo Cerpa and Lorena Varela-Nallar and Nibaldo C Inestrosa},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={239 1},
Wnt signaling regulates a wealth of aspects of nervous system development and function in embryonic stages and in adulthood. The expression of Wnt ligands and components of the Wnt signaling machinery in early stages of neural development has been related to its role in neurite patterning and in synaptogenesis. Moreover, its expression in the mature nervous system suggests a role for this pathway in synaptic maintenance and function. Therefore, it is of crucial relevance the understanding of… CONTINUE READING
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