Wnt signaling is a key mediator of Cdx1 expression in vivo.

@article{Pilon2007WntSI,
  title={Wnt signaling is a key mediator of Cdx1 expression in vivo.},
  author={Nicolas Pilon and Karen Y Oh and Jean-Ren{\'e} Sylvestre and Joanne G.A. Savory and David Lohnes},
  journal={Development},
  year={2007},
  volume={134 12},
  pages={
          2315-23
        }
}
In the mouse, Cdx1 is essential for normal anteroposterior vertebral patterning through regulation of a subset of Hox genes. Retinoic acid (RA) and certain Wnts have also been implicated in vertebral patterning, although the relationship between these signaling pathways and the regulation of mesodermal Hox gene expression is not fully understood. Prior work has shown that Cdx1 is a direct target of both Wnt and retinoid signaling pathways, and might therefore act to relay these signals to the… CONTINUE READING

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