Wnt signaling inhibits cementoblast differentiation and promotes proliferation.

  title={Wnt signaling inhibits cementoblast differentiation and promotes proliferation.},
  author={Eiji Nemoto and Yohei Koshikawa and Sousuke Kanaya and Masahiro Tsuchiya and Masato Tamura and Martha Joan Somerman and Hidetoshi Shimauchi},
  volume={44 5},
Cementoblasts, tooth root lining cells, are responsible for laying down cementum on the root surface, a process that is indispensable for establishing a functional periodontal ligament. Cementoblasts share phenotypical features with osteoblasts. Wnt signaling has been implicated in increased bone formation by controlling mesenchymal stem cell or osteoblastic cell functions; however the role of Wnt signaling on cementogenesis has not been examined. In this study, we have identified a consistent… CONTINUE READING


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