Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules.

@article{Weerkamp2006WntSI,
  title={Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules.},
  author={F. Weerkamp and M. R. Baert and B. A. Naber and E. E. Koster and E. D. de Haas and Kondala R. Atkuri and J. J. V. van Dongen and L. Herzenberg and F. J. Staal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 9},
  pages={
          3322-6
        }
}
  • F. Weerkamp, M. R. Baert, +6 authors F. J. Staal
  • Published 2006
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • Wnt signaling is essential for T cell development in the thymus, but the stages in which it occurs and the molecular mechanisms underlying Wnt responsiveness have remained elusive. Here we examined Wnt signaling activity in both human and murine thymocyte populations by determining beta-catenin levels, Tcf-reporter activation and expression of Wnt-target genes. We demonstrate that Wnt signaling occurs in all thymocyte subsets, including the more mature populations, but most prominently in the… CONTINUE READING

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