Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules.

@article{Weerkamp2006WntSI,
  title={Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules.},
  author={Floor Weerkamp and Miranda R. M. Baert and Brigitta A E Naber and Esther E.L. Koster and Edwin F.E. de Haas and Kondala R Atkuri and Jacques J. M. van Dongen and Leonard A. Herzenberg and Frank J. T. Staal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 9},
  pages={3322-6}
}
Wnt signaling is essential for T cell development in the thymus, but the stages in which it occurs and the molecular mechanisms underlying Wnt responsiveness have remained elusive. Here we examined Wnt signaling activity in both human and murine thymocyte populations by determining beta-catenin levels, Tcf-reporter activation and expression of Wnt-target genes. We demonstrate that Wnt signaling occurs in all thymocyte subsets, including the more mature populations, but most prominently in the… CONTINUE READING

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Expression levels of intracellular Wnt signaling molecules Relative mRNA expression levels of different Wnt signaling components in human thymocyte subsets determined by microarray analysis

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