Wnt signaling in axon guidance

@article{Zou2004WntSI,
  title={Wnt signaling in axon guidance},
  author={Yimin Zou},
  journal={Trends in Neurosciences},
  year={2004},
  volume={27},
  pages={528-532}
}
  • Y. Zou
  • Published 1 September 2004
  • Biology
  • Trends in Neurosciences

Figures from this paper

A β-Catenin-Dependent Wnt Pathway Mediates Anteroposterior Axon Guidance in C. elegans Motor Neurons
TLDR
Evidence is provided that Wnt-mediated axon guidance can be transduced through a β-catenin-dependent pathway.
Wnt signal transduction pathways
TLDR
The most recent advances in understanding of these Wnt signaling pathways are summarized and the role of these pathways in regulating key events during embryonic patterning and morphogenesis is summarized.
Derailed regulates development of the Drosophila neuromuscular junction
TLDR
It is shown here that Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor, and structure–function analyses of the Drl protein indicate that normal synaptic growth requires the extracellular Wnt inhibitory factor domain and the intracellular domain, which includes an atypical kinase.
Does planar cell polarity signaling steer growth cones?
  • Y. Zou
  • Biology
    Current topics in developmental biology
  • 2012
Syndecan functions to regulate Wnt-dependent axon guidance in C. elegans
TLDR
The results suggest syndecan is a component of Wnt-signaling events that are necessary for axons to recognize appropriate termination points and is likely cell autonomous to inhibit growth later in development.
Directional guidance of nerve growth cones
Celsr3 and Fzd3 in axon guidance.
...
...

References

SHOWING 1-10 OF 45 REFERENCES
Wnt-mediated axon guidance via the Drosophila Derailed receptor
TLDR
The results reveal an unexpected role in axon guidance for a Wnt family member, and show that the Derailed receptor is an essential component of Wnt signalling in these guidance events.
Mechanisms of Wnt signaling in development.
TLDR
Over the past two years the understanding of Wnt signaling has been substantially improved by the identification of Frizzled proteins as cell surface receptors for Wnts and by the finding that beta-catenin, a component downstream of the receptor, can translocate to the nucleus and function as a transcriptional activator.
WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons.
TLDR
It is reported here that Wnt-7a is expressed in cerebellar granule cell neurons as they begin to extend processes and form synapses, and it is proposed that WNT proteins have a novel function in the formation of neuronal connections.
Wnt5 is required for tail formation in the zebrafish embryo.
TLDR
It is shown that the zebrafish pipetail gene is identical to Wnt5, which suggests a major role for wnt5 in morphogenetic processes underlying tail outgrowth and cartilage differentiation in the head.
The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS.
TLDR
DWnt-3 encodes a secreted protein, which is likely to play a role in development of the Drosophila CNS, and is efficiently synthesized, glycosylated, proteolytically processed, and transported to the extracellular matrix and medium.
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
TLDR
It is shown that the zebrafish silberblick locus encodes Wnt11 and that Slb/Wnt11 activity is required for cells to undergo correct convergent extension movements during gastrulation, and that the correct extension of axial tissue is at least partly dependent on medio-lateral cell intercalation in paraxial tissue.
...
...