Wnt signaling controls the fate of mesenchymal stem cells.

  title={Wnt signaling controls the fate of mesenchymal stem cells.},
  author={L. Ling and Victor Nurcombe and Simon M Cool},
  volume={433 1-2},
Multipotential mesenchymal stem cells (MSCs) are able to differentiate along several known lineages and have been shown to be efficacious for in vivo wound repair. The growth and differentiation of MSCs are known to be tightly regulated via interactions with specific extracellular mediators. Recent studies have shown that Wnts and their downstream signaling pathways play an important role in the self-renewal and differentiation of MSCs. Indeed altered bone-mass is known to result from mutations… CONTINUE READING
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