Wnt signaling: relevance to β-cell biology and diabetes

  title={Wnt signaling: relevance to $\beta$-cell biology and diabetes},
  author={Hannah J. Welters and Rohit N. Kulkarni},
  journal={Trends in Endocrinology \& Metabolism},
Wnt signaling in pancreatic islets.
The Wnt signaling pathway is critically important not only for stem cell amplification, differentiation, and migration, but also is important for organogenesis and the development of the body plan.
Can we safely target the WNT pathway?
  • M. Kahn
  • Biology
    Nature Reviews Drug Discovery
  • 2014
The problems and potential solutions to the vexing situation of aberrant regulation of the WNT pathway are examined and a attempt is made to bring them into perspective.
Importance of β-Catenin in glucose and energy homeostasis
In settings of increased insulin demand, failure to expand pancreatic β-cells mass leads to diabetes. Genome-wide scans of diabetic populations have uncovered several genes associated with
Akt and PTEN: β-cell mass and pancreas plasticity
The Engimatic WNT signaling and Mesenchymal stem cell Adipogenesis: Implications for Metabolic Disorders
The present review focusses on the role of WNT signaling on Adipogenesis and its relationship with the development of metabolic disorders.
WNT/β-catenin increases the production of incretins by entero-endocrine cells
Lithium and WNT are incretin inducers in general and GIP is not a candidate for treatment but might be an important target from a prevention perspective, providing a novel link between WNT signalling, obesity and diabetes.
Cross-talk between Insulin and Wnt Signaling in Preadipocytes
Investigating cross-talk between insulin and Wnt signaling pathways using preadipocytes with and without knockdown of the Wnt co-receptors LRP5 and LRP6 finds that Wnt stimulation leads to phosphorylation of insulin signaling key mediators, although with a lower fold stimulation and slower time course than observed for insulin.


Wnt signaling regulates pancreatic β cell proliferation
Evidence is provided that Wnt signaling is both necessary and sufficient for islet β cell proliferation, and previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function is provided.
Regulation of pancreatic β‐cell function by the forkhead protein FoxO1
The data begin to outline an overarching role of FoxO1 in β‐cell function, which regulates β‐ cell proliferation and protects against β‐cells failure induced by oxidative stress through NeuroD and MafA induction.
Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?
This review will focus on the cross-regulation of AR and Wnt/beta-catenin/Tcf but will also consider the dynamic manner in which RAR/RXR, GR, TR, VDR, ER, and PPAR modulate canonical Wnt signaling.
Wnt5 signaling in vertebrate pancreas development
A novel role of Wnt signaling in organogenesis is reported using the formation of the islet during pancreatic development as a model tissue and the advantages of the zebrafish to visualize and document this process in living embryos.
Wnt/beta-catenin signaling.
  • T. Akiyama
  • Biology
    Cytokine & growth factor reviews
  • 2000
Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.
Evidence is provided that Wnt signaling is required for pancreatic growth but not adult beta-cell function.