Wnt signaling: is the party in the nucleus?

  title={Wnt signaling: is the party in the nucleus?},
  author={Karl Willert and Katherine A Jones},
  journal={Genes \& development},
  volume={20 11},
The Wnt signaling pathway controls cell proliferation and body patterning throughout development. A surprising number of cytoplasmic Wnt regulators (e.g., beta-catenin, Bcl-9/Lgs, APC, Axin) also appear, often transiently, in the nucleus. beta-Catenin is an integral component of E-cadherin complexes at intercellular adherens junctions, but also recruits chromatin remodeling complexes to activate transcription in the nucleus. The APC tumor suppressor is a part of the cytoplasmic beta-catenin… 

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