Wnt signaling: is the party in the nucleus?

@article{Willert2006WntSI,
  title={Wnt signaling: is the party in the nucleus?},
  author={K. Willert and K. Jones},
  journal={Genes \& development},
  year={2006},
  volume={20 11},
  pages={
          1394-404
        }
}
The Wnt signaling pathway controls cell proliferation and body patterning throughout development. A surprising number of cytoplasmic Wnt regulators (e.g., beta-catenin, Bcl-9/Lgs, APC, Axin) also appear, often transiently, in the nucleus. beta-Catenin is an integral component of E-cadherin complexes at intercellular adherens junctions, but also recruits chromatin remodeling complexes to activate transcription in the nucleus. The APC tumor suppressor is a part of the cytoplasmic beta-catenin… Expand
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References

SHOWING 1-10 OF 108 REFERENCES
A new nuclear component of the Wnt signalling pathway
TLDR
The discovery is reported of pygopus (pygo), whose mutant phenotypes specifically mimic loss-of-Wingless (Wg) signalling, and it is proposed that they mediate chromatin access to TCF or Arm/β-catenin. Expand
Wnt and calcium signaling: beta-catenin-independent pathways.
TLDR
This review will focus on the role of calcium in Wnt signaling and, as a consequence, provide a limited overview of beta-catenin-independent Wnt signaled pathways. Expand
Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex
TLDR
The results suggest that the recruitment of Pygo permits beta-catenin to transcriptionally activate Wnt target genes and raise the possibility that a deregulation of these events may play a causal role in the development of B cell malignancies. Expand
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.
TLDR
It is shown that Axin is dephosphorylated in response to Wnt signaling, which lowers Axin's affinity for beta-Catenin, thereby disengaging beta-catenin from the degradation machinery. Expand
The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.
TLDR
It is concluded that, in addition to regulating the stability of beta-cat, APC facilitates CtBP-mediated repression of Wnt target genes in normal, but not in colorectal cancer cells. Expand
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
TLDR
It is demonstrated here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL 9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-Caten in-dependent transcription. Expand
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin.
  • F. Cong, H. Varmus
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
The results suggest that Axin functions as a molecular chaperone for beta-catenin and that nuclear-cytoplasmic shuttling of Axin regulates the nuclear- Cytoplasmaic distribution of beta-Catenin. Expand
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
TLDR
Evidence is assembled of possible interrelations between Wnt and other growth factor signaling, β-catenin functions, and cadherin-mediated adhesion in tissue differentiation. Expand
Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes
TLDR
This model explains how cells can control whether β-catenin is used independently in cell adhesion and nuclear signaling, or competitively so that the two processes are coordinated and interrelated. Expand
Autoregulation of E-cadherin expression by cadherin–cadherin interactions
TLDR
This autoregulation of E-cadherin by cell–cell adhesion involving Slug, β-catenin and ERK could be important in tumorigenesis. Expand
...
1
2
3
4
5
...