Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell.

@article{Schlesinger1999WntPC,
  title={Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell.},
  author={Ayelet Schlesinger and Christopher A. Shelton and J N Maloof and Matteo Meneghini and Bruce Bowerman},
  journal={Genes & development},
  year={1999},
  volume={13 15},
  pages={2028-38}
}
In a four-cell-stage Caenorhabditis elegans embryo, Wnt signaling polarizes an endoderm precursor called EMS. The polarization of this cell orients its mitotic spindle in addition to inducing endodermal fate in one daughter cell. Reducing the function of Wnt pathway genes, including a newly identified GSK-3beta homolog called gsk-3, disrupts endoderm induction, whereas only a subset of these genes is required for proper EMS mitotic spindle orientation. Wnt pathway genes thought to act… CONTINUE READING
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