Wnt ligands signal in a cooperative manner to promote foregut organogenesis.

@article{Miller2012WntLS,
  title={Wnt ligands signal in a cooperative manner to promote foregut organogenesis.},
  author={Mayumi F. Miller and Ethan David Cohen and Julie E. Baggs and Min Min Lu and John B. Hogenesch and Edward E Morrisey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 38},
  pages={
          15348-53
        }
}
Endoderm-mesenchyme cross-talk is a central process in the development of foregut-derived organs. How signaling pathways integrate the activity of multiple ligands to guide organ development is poorly understood. We show that two Wnt ligands, Wnt2 and Wnt7b, cooperatively induce Wnt signaling without affecting the stabilization of the Wnt canonical effector β-catenin despite it being necessary for Wnt2-Wnt7b cooperativity. Wnt2-Wnt7b cooperation is specific for mesenchymal cell lineages and the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

beta-Catenin promotes respiratory progenitor identity in mouse foregut.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
VIEW 1 EXCERPT

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