Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy.

  title={Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy.},
  author={Nagato Sato and Takumi Yamabuki and Atsushi Takano and Junkichi Koinuma and Masato Aragaki and Ken Masuda and Nobuhisa Ishikawa and Nobuoki Kohno and Hiroyuki Ito and Masaki Miyamoto and Haruhiko Nakayama and Yohei Miyagi and Eiju Tsuchiya and Satoshi Kondo and Yusuke Nakamura and Yataro Daigo},
  journal={Cancer research},
  volume={70 13},
Dickkopf-1 (DKK1) is an inhibitor of Wnt/beta-catenin signaling that is overexpressed in most lung and esophageal cancers. Here, we show its utility as a serum biomarker for a wide range of human cancers, and we offer evidence favoring the potential application of anti-DKK1 antibodies for cancer treatment. Using an original ELISA system, high levels of DKK1 protein were found in serologic samples from 906 patients with cancers of the pancreas, stomach, liver, bile duct, breast, and cervix… CONTINUE READING

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