Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF.

  title={Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF.},
  author={Jurian Schuijers and Michal Mokry and Pantelis Hatzis and Edwin Cuppen and Hans Clevers},
  journal={The EMBO journal},
  volume={33 2},
Active canonical Wnt signaling results in recruitment of β-catenin to DNA by TCF/LEF family members, leading to transcriptional activation of TCF target genes. However, additional transcription factors have been suggested to recruit β-catenin and tether it to DNA. Here, we describe the genome-wide pattern of β-catenin DNA binding in murine intestinal epithelium, Wnt-responsive colorectal cancer (CRC) cells and HEK293 embryonic kidney cells. We identify two classes of β-catenin binding sites… CONTINUE READING
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