Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.

@article{Willert1999WntinducedDO,
  title={Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.},
  author={Karl Willert and Sayumi Shibamoto and Roeland Nusse},
  journal={Genes & development},
  year={1999},
  volume={13 14},
  pages={1768-73}
}
The stabilization of beta-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3beta are implicated in regulating beta-catenin phosphorylation and its subsequent degradation. Wnt signaling stabilizes beta-catenin, but it was not clear whether and how Wnt signaling regulates the beta-catenin complex. Here we show that Axin is dephosphorylated in response to Wnt signaling. The… CONTINUE READING
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