Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.

  title={Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.},
  author={K. Willert and S. Shibamoto and R. Nusse},
  journal={Genes & development},
  volume={13 14},
  • K. Willert, S. Shibamoto, R. Nusse
  • Published 1999
  • Medicine, Biology
  • Genes & development
  • The stabilization of beta-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3beta are implicated in regulating beta-catenin phosphorylation and its subsequent degradation. Wnt signaling stabilizes beta-catenin, but it was not clear whether and how Wnt signaling regulates the beta-catenin complex. Here we show that Axin is dephosphorylated in response to Wnt signaling. The… CONTINUE READING

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