Wnt-dependent regulation of the E-cadherin repressor snail.

  title={Wnt-dependent regulation of the E-cadherin repressor snail.},
  author={Jong In Yook and Xiao-yan Li and Ichiro Ota and Eric R. Fearon and Stephen J Weiss},
  journal={The Journal of biological chemistry},
  volume={280 12},
Down-regulation of E-cadherin marks the initiation of the epithelial-mesenchymal transition, a process exploited by invasive cancer cells. The zinc finger transcription factor, Snail, functions as a potent repressor of E-cadherin expression that can, acting alone or in concert with the Wnt/beta-catenin/T cell factor axis, induce an epithelial-mesenchymal transition. Although mechanisms that coordinate signaling events initiated by Snail and Wnt remain undefined, we demonstrate that Snail… CONTINUE READING
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21113-21123 9 by gest on O cber 1, 2017 hp://w w w .jb.org/ D ow nladed from Wnt/GSK3 TrCP-dependent regulation of Snail

H. Peinado, M. Quintanilla, A. Cano
J. Biol. Chem • 2003

hp://w w w .jb.org/ D ow nladed from Wnt/GSK3 TrCP-dependent regulation of Snail

Cell Biol • 2000

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