Wnt and hedgehog signaling pathways in bone development.

@article{Day2008WntAH,
  title={Wnt and hedgehog signaling pathways in bone development.},
  author={Timothy F Day and Yingzi Yang},
  journal={The Journal of bone and joint surgery. American volume},
  year={2008},
  volume={90 Suppl 1},
  pages={19-24}
}
Cell-cell signaling is a major strategy that vertebrate embryos employ to coordinately control cell proliferation, differentiation, and survival in many developmental processes. Similar cell signaling pathways also control adult tissue regeneration and repair. We demonstrated in the developing skeletal system that the Wnt/beta-catenin signaling controls the differentiation of progenitor cells into either osteoblasts or chondrocytes. Genetic ablation of beta-catenin in the developing mouse… CONTINUE READING

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