Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy

@inproceedings{Zhu2013WntAR,
  title={Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy},
  author={Shouan Zhu and Huanhuan Liu and Yan Wu and Boon Chin Heng and Pengfei Chen and Hua Liu and Hongwei Ouyang},
  booktitle={Arthritis research & therapy},
  year={2013}
}
Wnt and Rho GTPase signaling play critical roles in governing numerous aspects of cell physiology, and have been shown to be involved in endochondral ossification and osteoarthritis (OA) development. In this review, current studies of canonical Wnt signaling in OA development, together with the differential roles of Rho GTPases in chondrocyte maturation and OA pathology are critically summarized. Based on the current scientific literature together with our preliminary results, the strategy of… CONTINUE READING