Wnt activator FOXB2 drives prostate cancer neuroendocrine differentiation

@article{Moparthi2019WntAF,
  title={Wnt activator FOXB2 drives prostate cancer neuroendocrine differentiation},
  author={Lavanya Moparthi and Giulia Pizzolato and Stefan Koch},
  journal={bioRxiv},
  year={2019}
}
The Wnt signaling pathway is of paramount importance for development and disease. However, the tissue-specific regulation of Wnt pathway activity remains incompletely understood. Here we identify FOXB2, an uncharacterized forkhead box family transcription factor, as a potent activator of Wnt signaling in normal and cancer cells. Mechanistically, FOXB2 induces the non-classical Wnt ligand WNT7B, which increases TCF/LEF-dependent transcription without activating LRP6 or β-catenin. Proximity… 
Forkhead box B2 inhibits the malignant characteristics of the pancreatic cancer cell line Panc‐1 in vitro
TLDR
FoxB2 has the ability to inhibit the malignant characteristics of Panc‐1 in vitro, and this work suggests that it acts as a tumor suppressor.

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