Wnt activation in nail epithelium couples nail growth to digit regeneration

@article{Takeo2013WntAI,
  title={Wnt activation in nail epithelium couples nail growth to digit regeneration},
  author={Makoto Takeo and W. Chou and Qi Sun and Wendy Lee and P. Rabbani and C. Loomis and M. Taketo and Mayumi Ito},
  journal={Nature},
  year={2013},
  volume={499},
  pages={228 - 232}
}
The tips of mammalian digits can regenerate after amputation, like those of amphibians. It is unknown why this capacity is limited to the area associated with the nail. Here we show that nail stem cells (NSCs) reside in the proximal nail matrix and that the mechanisms governing NSC differentiation are coupled directly with their ability to orchestrate digit regeneration. Early nail progenitors undergo Wnt-dependent differentiation into the nail. After amputation, this Wnt activation is required… Expand
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