Wnt activates the Tak1/Nemo-like kinase pathway.

  title={Wnt activates the Tak1/Nemo-like kinase pathway.},
  author={Linda Smit and Annette Baas and Jeroen Kuipers and Hendrik C. Korswagen and Marc van de Wetering and Hans Clevers},
  journal={The Journal of biological chemistry},
  volume={279 17},
Genetic studies on endoderm-mesoderm specification in Caenorhabditis elegans have demonstrated a role for several Wnt cascade components as well as for a MAPK-like pathway in this process. The latter pathway includes the MAPK kinase kinase-like MOM-4/Tak1, its adaptor TAP-1/Tab1, and the MAPK-like LIT-1/Nemo-like kinase. A model has been proposed in which the Tak1 kinase cascade counteracts the Wnt cascade at the level of beta-catenin/TCF phosphorylation. In this model, the signal that… CONTINUE READING

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