Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).

@article{Yang2015WntFrizzledplanarCP,
  title={Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).},
  author={Yingzi Yang and Marek Mlodzik},
  journal={Annual review of cell and developmental biology},
  year={2015},
  volume={31},
  pages={623-46}
}
The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a critical, evolutionarily conserved process during development and organogenesis. Analyses in Drosophila and several vertebrate model organisms have contributed a wealth of information on the regulation of PCP. A key conserved pathway regulating PCP, the so-called core Wnt-Frizzled PCP (Fz/PCP) signaling pathway, was initially identified through genetic studies of Drosophila. PCP studies in vertebrates, most… CONTINUE READING

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