Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons.

  title={Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons.},
  author={Francisco J Mu{\~n}oz and Juan Alejandro Godoy and Waldo Cerpa and In{\'e}s M. Poblete and Juan Pablo Huidobro-Toro and Nibaldo C. Inestrosa},
  journal={Biochemical and biophysical research communications},
  volume={444 2},
Wnt signaling has a crucial role in synaptic function at the central nervous system. Here we evaluate whether Wnts affect nitric oxide (NO) generation in hippocampal neurons. We found that non-canonical Wnt-5a triggers NO production; however, Wnt-3a a canonical ligand did not exert the same effect. Co-administration of Wnt-5a with the soluble Frizzled related protein-2 (sFRP-2) a Wnt antagonist blocked the NO production. Wnt-5a activates the non-canonical Wnt/Ca(2+) signaling through a… CONTINUE READING
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