Wnt-5a has tumor suppressor activity in thyroid carcinoma

  title={Wnt-5a has tumor suppressor activity in thyroid carcinoma},
  author={Natalia Kremenevskaja and Reinhard von Wasielewski and A. Suresh Rao and Christof Sch{\"o}fl and Tommy Andersson and Georg Brabant},
Stabilization of β-catenin by inhibition of its phosphorylation is characteristic of an activation of the canonical Wnt/β-catenin signaling pathway and is associated with various human carcinomas. It contrasts to an as yet incompletely characterized action of an alternative noncanonical Wnt signaling pathway on neoplastic transformation. The aim of the present study was to test the effects of a member of the noncanonical Wnt signaling pathway, Wnt-5a, in primary thyroid carcinomas and in… CONTINUE READING


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