Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.

@article{Murdoch2003Wnt5AAR,
  title={Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.},
  author={Barbara Murdoch and Kristin Chadwick and Matthew Martin and Farbod Shojaei and Kavita V. Shah and Lisa M. Gallacher and Randall T. Moon and Mickie Bhatia},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 6},
  pages={3422-7}
}
Human hematopoietic stem cells are defined by their ability to repopulate multiple hematopoietic lineages in the bone marrow of transplanted recipients and therefore are functionally distinct from hematopoietic progenitors detected in vitro. Although factors capable of regulating progenitors are well established, in vivo regulators of hematopoietic repopulating function are unknown. By using a member of the vertebrate Wnt family, Wnt-5A, the proliferation and differentiation of progenitors… CONTINUE READING

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