Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1

@article{Sim2002Wnt4RB,
  title={Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1},
  author={Edmund U-H Sim and Aaron Smith and Elida Szilagi and Fiona Rae and Panos A. Ioannou and Megan H Lindsay and Melissa H Little},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={2948-2960}
}
The Wilms' tumour suppressor gene, WT1, encodes multiple nuclear protein isoforms, all containing four C-terminal zinc finger motifs. WT1 proteins can both activate and repress putative target genes in vitro, although the in vivo relevance of these putative target genes is often unverified. WT1 mutations can result in Wilms' tumour and the Denys-Drash Syndrome (DDS) of infantile nephropathy, XY pseudohermaphroditism and predisposition to Wilms' tumour. We have established stable transfectants… CONTINUE READING

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