Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression.

@article{Nagy2010Wnt11SC,
  title={Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression.},
  author={Irina I. Nagy and Antti Railo and Risto Rapila and Terhi Hast and Raija T. Sormunen and Pasi Tavi and Juha R{\"a}s{\"a}nen and Seppo J Vainio},
  journal={Cardiovascular research},
  year={2010},
  volume={85 1},
  pages={100-9}
}
AIMS The stage-dependent organization of the cardiomyocytes during formation of the different layers of the developing ventricular wall is critical for the establishment of a functional heart, but the instructive signals involved are still poorly known. We have addressed the potential role of Wnt-11 in the control of early ventricular myocardium assembly. METHODS AND RESULTS We demonstrate by means of expression analysis and a mouse model in which Wnt-11 function has been inactivated that Wnt… CONTINUE READING
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