Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells

@inproceedings{UysalOnganer2009Wnt11PN,
  title={Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells},
  author={Pinar Uysal-Onganer and Yoshiaki Kawano and Mercedes Inda Caro and Marjorie M Walker and Soraya Diez and R Siobhan Darrington and Jonathan A. Waxman and Robert M Kypta},
  booktitle={Molecular Cancer},
  year={2009}
}
Wnt-11 is a secreted protein that modulates cell growth, differentiation and morphogenesis during development. We previously reported that Wnt-11 expression is elevated in hormone-independent prostate cancer and that the progression of prostate cancer from androgen-dependent to androgen-independent proliferation correlates with a loss of mutual inhibition between Wnt-11- and androgen receptor-dependent signals. However, the prevalence of increased expression of Wnt-11 in patient tumours and the… CONTINUE READING

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