Wnt/beta-catenin signaling mediates oval cell response in rodents.

@article{Apte2008WntbetacateninSM,
  title={Wnt/beta-catenin signaling mediates oval cell response in rodents.},
  author={Udayan M Apte and Michael D. Thompson and Shanshan Cui and Bowen Liu and Benjamin W Cieply and Satdarshan P. S. Monga},
  journal={Hepatology},
  year={2008},
  volume={47 1},
  pages={288-95}
}
UNLABELLED Adult hepatic stem cells or oval cells are facultative stem cells in the liver that are activated during regeneration only during inhibition of innate hepatocyte proliferation. On the basis of its involvement in liver cancer, regeneration, and development, we investigated the role of the Wnt/beta-catenin pathway in oval cell response, which was initiated in male Fisher rats with 2-acetylaminofluorine and two-third partial hepatectomy (PHX). Extensive oval cell activation and… CONTINUE READING

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