Wnt/beta-catenin signaling is required for development of the exocrine pancreas.

Abstract

BACKGROUND Beta-catenin is an essential mediator of canonical Wnt signaling and a central component of the cadherin-catenin epithelial adhesion complex. Dysregulation of beta-catenin expression has been described in pancreatic neoplasia. Newly published studies have suggested that beta-catenin is critical for normal pancreatic development although these… (More)

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