Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.

Abstract

Wnt/β-catenin signaling plays a major role in the development of the nervous system and contributes to neuronal plasticity. However, its role in myelination remains unclear. Here, we identify the Wnt/β-catenin pathway as an essential driver of myelin gene expression. The selective inhibition of Wnt components by small interfering RNA or dominant-negative… (More)
DOI: 10.1523/JNEUROSCI.4270-10.2011

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