Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.

@article{Mak2006WntbetacateninSI,
  title={Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.},
  author={Kingston Kinglun Mak and M J Chen and Timothy F Day and Pao-Tien Chuang and Yingzi Yang},
  journal={Development},
  year={2006},
  volume={133 18},
  pages={3695-707}
}
Both the Wnt/beta-catenin and Ihh signaling pathways play essential roles in crucial aspects of endochondral ossification: osteoblast differentiation, chondrocyte proliferation and hypertrophy. To understand the genetic interaction between these two signaling pathways, we have inactivated the beta-catenin gene and upregulated Ihh signaling simultaneously in the same cells during endochondral skeletal development using beta-catenin and patched 1 floxed alleles. We uncovered previously unexpected… CONTINUE READING