Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells.

@article{ajnek2009WntbetacateninSB,
  title={Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells.},
  author={Luk{\'a}{\vs} {\vC}aj{\'a}nek and Diogo J. P. Ribeiro and Isabel Liste and Clare L. Parish and V{\'i}tězslav Bryja and Ernest Arenas},
  journal={Stem cells},
  year={2009},
  volume={27 12},
  pages={2917-27}
}
Embryonic stem cells (ESCs) represent not only a promising source of cells for cell replacement therapy, but also a tool to study the molecular mechanisms underlying cellular signaling and dopaminergic (DA) neuron development. One of the main regulators of DA neuron development is Wnt signaling. Here we used mouse ESCs (mESCs) lacking Wnt1 or the low-density lipoprotein receptor-related protein 6 (LRP6) to decipher the action of Wnt/beta-catenin signaling on DA neuron development in mESCs. We… CONTINUE READING
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