Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells.

@article{Fevr2007WntbetacateninIE,
  title={Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells.},
  author={Tea Fevr and Sylvie Robine and Daniel Louvard and Joerg Huelsken},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 21},
  pages={7551-9}
}
The Wnt signaling pathway is deregulated in over 90% of human colorectal cancers. beta-Catenin, the central signal transducer of the Wnt pathway, can directly modulate gene expression by interacting with transcription factors of the TCF/LEF family. In the present study we investigate the role of Wnt signaling in the homeostasis of intestinal epithelium by using tissue-specific, inducible beta-catenin gene ablation in adult mice. Block of Wnt/beta-catenin signaling resulted in rapid loss of… CONTINUE READING
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