Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.

@article{Gaujoux2008WntbetacateninA3,
  title={Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.},
  author={S{\'e}bastien Gaujoux and Fr{\'e}d{\'e}rique Tissier and Lionel Groussin and Rossella Lib{\'e} and Bruno Ragazzon and Pierre Launay and Anne Audebourg and Bertrand Dousset and Xavier Y Bertagna and J{\'e}r{\^o}me Bertherat},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 10},
  pages={4135-40}
}
BACKGROUND The Wnt/beta-catenin and cAMP signaling pathways play an important role in adrenal cortex tumorigenesis. Somatic activating mutations of the beta-catenin gene (CTNNB1) are the most frequent genetic defects identified both in adrenocortical adenomas (ACAs) and adrenocortical cancers (ACCs). PRKAR1A mutations leading to cAMP pathway dysregulation are observed in primary pigmented nodular adrenocortical diseases (PPNADs) and some sporadic ACAs. OBJECTIVE The objective of the… CONTINUE READING

Citations

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The Wnt/beta-catenin pathway in adrenocortical development and cancer.

Molecular and cellular endocrinology • 2011
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Highly Influenced

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Endocrinology and metabolism clinics of North America • 2017
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Somatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity.

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