Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

Abstract

Wnt/Wingless (Wg) signals are transduced by seven-transmembrane Frizzleds (Fzs) and the single-transmembrane LDL-receptor-related proteins 5 or 6 (LRP5/6) or Arrow. The aminotermini of LRP and Fz were reported to associate only in the presence of Wnt, implying that Wnt ligands form a trimeric complex with two different receptors. However, it was recently… (More)
DOI: 10.1186/1471-2121-4-4

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