Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

@article{Kramps2002WntWinglessSR,
  title={Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear $\beta$-Catenin-TCF Complex},
  author={Thomas Kramps and Oliver Peter and Erich Brunner and Denise Nellen and Barbara A. Froesch and Sandipan Chatterjee and Maximilien Murone and Stephanie Z{\"u}llig and Konrad Basler},
  journal={Cell},
  year={2002},
  volume={109},
  pages={47-60}
}
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It is inferred that the β-catenin/Lgs binding site may serve as an attractive drug target for therapeutic intervention in β- catenin-dependent cancer progression.
Pygopus Residues Required for its Binding to Legless Are Critical for Transcription and Development*
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Four conserved residues at the putative PHD domain surface of Drosophila and mouse Pygopus that are required for their binding to Legless in vitro and in vivo are identified and defined as a specific molecular target for blocking Wnt signaling during development and cancer.
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