# Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

@article{Kramps2002WntWinglessSR,
title={Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear $\beta$-Catenin-TCF Complex},
author={Thomas Kramps and Oliver Peter and Erich Brunner and Denise Nellen and Barbara A. Froesch and Sandipan Chatterjee and Maximilien Murone and Stephanie Z{\"u}llig and Konrad Basler},
journal={Cell},
year={2002},
volume={109},
pages={47-60}
}
• Published 5 April 2002
• Biology
• Cell
582 Citations

## Figures from this paper

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Four conserved residues at the putative PHD domain surface of Drosophila and mouse Pygopus that are required for their binding to Legless in vitro and in vivo are identified and defined as a specific molecular target for blocking Wnt signaling during development and cancer.
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## References

SHOWING 1-10 OF 73 REFERENCES
pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
• Biology
Nature
• 1997
The results indicate that Pan is an essential component of the Wg transduction pathway and suggest that it acts directly to regulate gene transcription in response to Wg signalling.
Mechanisms of Wnt signaling in development.
• Biology
Annual review of cell and developmental biology
• 1998
Over the past two years the understanding of Wnt signaling has been substantially improved by the identification of Frizzled proteins as cell surface receptors for Wnts and by the finding that beta-catenin, a component downstream of the receptor, can translocate to the nucleus and function as a transcriptional activator.
Drosophila Apc2 Is a Cytoskeletally-Associated Protein That Regulates Wingless Signaling in the Embryonic Epidermis
• Biology
The Journal of cell biology
• 1999
Drosophila APC (dAPC) negatively regulates Arm signaling, but only in a limited set of tissues, and a second fly APC, dAPC2, which binds Arm and is expressed in a broad spectrum of tissues is described, revealing a negative regulator of Wg signaling in the embryonic epidermis.
Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes.
• Biology
Genes & development
• 2000
It is reported here that the product of the trithorax group gene osa is required to repress genes in the absence of the Wingless signal, suggesting that altering the conformation of chromatin is an important mechanism by which Wingless signaling activates gene expression.
Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein.
• Biology
Proceedings of the National Academy of Sciences of the United States of America
• 1998
Evidence is provided for an in vivo multiprotein complex composed of Pontin52, beta-catenin, and lymphocyte enhancer factor-1/T-cell factor, and the results suggest involvement ofPontin52 in the nuclear function of beta- catenin.
Nuclear Localization and Formation of β-Catenin–Lymphoid Enhancer Factor 1 Complexes Are Not Sufficient for Activation of Gene Expression
• Biology
Molecular and Cellular Biology
• 1999
It is demonstrated here that β-catenin can be imported into the nucleus independently of LEF/TCF binding, and it may also be exported from nuclei, suggesting that a third component is necessary for gene activation and that this third component may vary with cell type.
Components of wingless signalling in Drosophila
• Biology
Nature
• 1994
This work has investigated the requirement in the Wg signal transduction pathway for the three genes armadillo (arm), dishevelled (dsh) and porcupine (porc)13, all of which have embryonic mutant phenotypes similar to wg and results indicate that dsh and porc act upstream of zw3, and arm acts downstream of zW3.
Functional Characterization of Multiple Transactivating Elements in β-Catenin, Some of Which Interact with the TATA-binding Proteinin Vitro *
• Biology
The Journal of Biological Chemistry
• 1999
It is shown that β-catenin's transactivation domains possess a modular structure, consist of multiple subelements that cover broad regions at its N and C termini, and extend considerably into the Armadillo repeat region, providing further evidence that a major function of β-Catenin during Wnt signaling is to recruit the basal transcription machinery to promoter regions of Wnt target genes.
Wnt signaling is required for thymocyte development and activates Tcf‐1 mediated transcription
• Biology
European journal of immunology
• 2001
It is shown that the interaction of β‐catenin with Tcf‐1 is required for full thymocyte development, and this interaction may be established by signals mediated by Wnt1 and Wnt4, leading to increased TCF‐dependent transcriptional activity in thymocytes, as demonstrated in Tcf-LacZ reporter mice.