Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain.

@article{Hill2015WntNotumSF,
  title={Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain.},
  author={Eric M Hill and Christian P Petersen},
  journal={Development},
  year={2015},
  volume={142 24},
  pages={4217-29}
}
Mechanisms determining final organ size are poorly understood. Animals undergoing regeneration or ongoing adult growth are likely to require sustained and robust mechanisms to achieve and maintain appropriate sizes. Planarians, well known for their ability to undergo whole-body regeneration using pluripotent adult stem cells of the neoblast population, can reversibly scale body size over an order of magnitude by controlling cell number. Using quantitative analysis, we showed that after injury… CONTINUE READING
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Experimental Studies of the Regeneration of Planaria Maculata

  • T. H. Morgan
  • Arch Entw Mech Org 7, 364–397.
  • 1898
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