Wnt/IL‐1β/IL‐8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5

@article{Miloevi2019WntIL1IL8AC,
  title={Wnt/IL‐1$\beta$/IL‐8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5},
  author={Vladan D. Milo{\vs}evi{\'c} and Joanna Kopecka and Iris Chiara Salaroglio and Roberta Libener and Francesca Napoli and Stefania Izzo and Sara Orecchia and Preeta Ananthanarayanan and Paolo Bironzo and Federica Grosso and Fabrizio Tabb{\`o} and Valentina Comunanza and Teodora Alexa-Stratulat and Federico Bussolino and Luisella Righi and Silvia Novello and Giorgio Vittorio Scagliotti and Chiara Riganti},
  journal={International Journal of Cancer},
  year={2019},
  volume={146}
}
Malignant pleural mesothelioma (MPM) is a tumor with high chemoresistance and poor prognosis. MPM‐initiating cells (ICs) are known to be drug resistant, but it is unknown if and how stemness‐related pathways determine chemoresistance. Moreover, there are no predictive markers of IC‐associated chemoresistance. Aim of this work is to clarify if and by which mechanisms the chemoresistant phenotype of MPM IC was due to specific stemness‐related pathways. We generated MPM IC from primary MPM samples… 
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