Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.

@article{Gregory2010WntCa2NFATSM,
  title={Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.},
  author={Mark A Gregory and Tzu L. Phang and Paolo Neviani and Francesca Alvarez-Calderon and Christopher A. Eide and Thomas O'Hare and Vadym Zaberezhnyy and Richard T. Williams and Brian J. Druker and Danilo Perrotti and James V Degregori},
  journal={Cancer cell},
  year={2010},
  volume={18 1},
  pages={74-87}
}
Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to eradicate Bcr-Abl(+) leukemia cells. To identify genes whose inhibition sensitizes Bcr-Abl(+) leukemias to killing by Bcr-Abl inhibitors, we performed an RNAi-based synthetic lethal screen with imatinib mesylate in CML cells. This screen identified numerous components of a Wnt/Ca(2+)/NFAT signaling pathway. Antagonism of this pathway led to impaired NFAT activity… CONTINUE READING
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