Wnt/β-catenin signalling in prostate cancer

@article{Kypta2012WntcateninSI,
  title={Wnt/β-catenin signalling in prostate cancer},
  author={Robert M Kypta and Jonathan A. Waxman},
  journal={Nature Reviews Urology},
  year={2012},
  volume={9},
  pages={418-428}
}
The Wnts are secreted cysteine-rich glycoproteins that have important roles in the developing embryo as well as in tissue homeostasis in adults. Dysregulation of Wnt signalling can lead to several types of cancer, including prostate cancer. A hallmark of the signalling pathway is the stabilization of the transcriptional co-activator β-catenin, which not only regulates expression of many genes implicated in cancer but is also an essential component of cadherin cell adhesion complexes. β-catenin… CONTINUE READING
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