Wnt/β-catenin signalling in prostate cancer

  title={Wnt/β-catenin signalling in prostate cancer},
  author={Robert M Kypta and Jonathan A. Waxman},
  journal={Nature Reviews Urology},
The Wnts are secreted cysteine-rich glycoproteins that have important roles in the developing embryo as well as in tissue homeostasis in adults. Dysregulation of Wnt signalling can lead to several types of cancer, including prostate cancer. A hallmark of the signalling pathway is the stabilization of the transcriptional co-activator β-catenin, which not only regulates expression of many genes implicated in cancer but is also an essential component of cadherin cell adhesion complexes. β-catenin… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 163 references

Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2012

Cancer statistics, 2012.

CA: a cancer journal for clinicians • 2012

Structural basis of coactivation of liver receptor homolog-1 by β-catenin

F Yumoto
Proc. Natl Acad. Sci. USA 109, • 2012

Targeting protein lipidation in disease.

Trends in molecular medicine • 2012

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