Wnt/β-catenin signaling triggers neuron reprogramming and regeneration in the mouse retina.

@article{Sanges2013WntcateninST,
  title={Wnt/β-catenin signaling triggers neuron reprogramming and regeneration in the mouse retina.},
  author={Daniela Sanges and Neus Romo and Giacoma Simonte and Umberto di Vicino and Ariadna Diaz Tahoces and Eduardo Fern{\'a}ndez and Maria Pia Cosma},
  journal={Cell reports},
  year={2013},
  volume={4 2},
  pages={271-86}
}
Cell-fusion-mediated somatic-cell reprogramming can be induced in culture; however, whether this process occurs in mammalian tissues remains enigmatic. Here, we show that upon activation of Wnt/β-catenin signaling, mouse retinal neurons can be transiently reprogrammed in vivo back to a precursor stage. This occurs after their spontaneous fusion with transplanted hematopoietic stem and progenitor cells (HSPCs). Moreover, we demonstrate that retinal damage is essential for cell-hybrid formation… CONTINUE READING
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