Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

@article{Yuasa2008WntcateninSS,
  title={Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration},
  author={Takahito Yuasa and Tomohiro Otani and Tatsuya Koike and Masahiro Iwamoto and Motomi Enomoto-Iwamoto},
  journal={Laboratory Investigation},
  year={2008},
  volume={88},
  pages={264-274}
}
A fine balance between anabolic and catabolic mechanisms maintains extracellular matrix homeostasis in articular cartilage, and shifts toward degradation are associated with joint conditions such as osteoarthritis. To test the possible involvement, relevance and significance of the Wnt/β-catenin-signaling pathway in those catabolic shifts, rabbit articular chondrocyte cultures were subjected to experimental activation of β-catenin signaling by Wnt3A treatment or forced expression of… CONTINUE READING