Wnt/β-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells.

@article{Nakatsu2011WntcateninSR,
  title={Wnt/$\beta$-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells.},
  author={M. N. Nakatsu and Z. Ding and M. Ng and T. Truong and F. Yu and S. Deng},
  journal={Investigative ophthalmology \& visual science},
  year={2011},
  volume={52 7},
  pages={
          4734-41
        }
}
PURPOSE To investigate the expression and role of the Wnt signaling pathway in human limbal stem cells (LSCs). METHODS Total RNA was isolated from the human limbus and central cornea. Limbal or cornea-specific transcripts were identified through quantitative real-time PCR. Protein expression of Wnt molecules was confirmed by immunohistochemistry on human ocular tissue. Activation of Wnt signaling using lithium chloride was achieved in vitro and its effects on LSC differentiation and… Expand

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