Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease.

@article{LEpiscopo2014WntcateninSI,
  title={Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease.},
  author={Francesca L'Episcopo and Cataldo Tirolo and Nunzio Testa and Salvatore Caniglia and Maria Concetta Morale and Maria Francesca Serapide and Stefano Pluchino and Bianca Marchetti},
  journal={Stem cells},
  year={2014},
  volume={32 8},
  pages={2147-63}
}
Wnt/β-catenin signaling is required for specification and neurogenesis of midbrain dopaminergic (mDA) neurons, the pivotal neuronal population that degenerates in Parkinson's disease (PD), and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. Wnt/β-catenin signaling plays a vital role in adult neurogenesis but whether it might engage DA neurogenesis/neurorepair in the affected PD brain is yet unresolved. Recently, the adult midbrain aqueduct periventricular regions (Aq… CONTINUE READING
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